Detailed view for EmuJ_000753500

Basic information

TDR Targets ID: 957935
Echinococcus multilocularis, protein piccolo
Source Database / ID:  GeneDB

pI: 6.2277 | Length (AA): 1841 | MW (Da): 202805 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain
PF00595   PDZ domain (Also known as DHR or GLGF)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

Insulin secretion (KEGG)

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1132 1264 2kr0 (A) 186 319 29.00 0.19 0.02 0.0311433 2.16
1358 1461 2daz (A) 11 106 32.00 0.042 1 0.441391 -0.62
1367 1465 1ujd (A) 9 108 40.00 0 1 0.580675 -0.74
1386 1469 1um1 (A) 17 99 28.00 0.01 0.89 0.472527 -0.85
1386 1473 1pdr (A) 472 554 30.00 0.59 0.98 0.4857 -1.17
1660 1789 1rh8 (A) 4637 4771 42.00 0 1 0.489614 -0.01
1661 1788 4ts6 (A) 0 961 34.00 0.000000000053 1 0.541427 -0.69
1664 1789 3fdw (A) 358 481 29.00 0.00032 0.89 0.429341 -0.29
1664 1825 2r83 (A) 143 299 20.00 0 0.6 0.279996 0.04
1664 1788 2uzp (A) 159 277 44.00 0 1 0.520798 -0.3
1675 1837 1cjy (B) 1016 1171 17.00 0 0.25 0.167539 -0.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132209)

Species Accession Gene Product
Brugia malayi Bm1_40670   C2 domain containing protein
Echinococcus granulosus EgrG_000753500   protein piccolo
Echinococcus multilocularis EmuJ_000753500   protein piccolo
Homo sapiens ENSG00000186472   piccolo presynaptic cytomatrix protein
Homo sapiens ENSG00000164061   bassoon presynaptic cytomatrix protein
Loa Loa (eye worm) LOAG_05037   hypothetical protein
Mus musculus ENSMUSG00000061601   piccolo (presynaptic cytomatrix protein)
Mus musculus ENSMUSG00000032589   bassoon
Schistosoma japonicum Sjp_0316940   IPR000008,C2 calcium-dependent membrane targeting;IPR008973,C2 calcium/lipid-binding region, CaLB,domain-containing
Schistosoma japonicum Sjp_0070690   Protein piccolo, putative
Schistosoma mansoni Smp_151430   hypothetical protein
Schmidtea mediterranea mk4.010547.00   Protein piccolo
Schmidtea mediterranea mk4.027391.00  
Schmidtea mediterranea mk4.029721.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0109 0.4866 0.4866
0.005 0.2612 0.2612
0.0058 0.5 0.5
0.0107 0.5 0.5
0.0121 1 1
0.0071 0.2549 0.2498
0.0125 0.3893 0.9758
0.0072 0.2639 0.2639
0.0018 0.5 0.5
0.0057 0.3491 0.3491

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000753500 (Echinococcus multilocularis), protein piccolo
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